Results

Publications

2016

LINK TOPIC TITLE REFERENCE AUTHOR(S) DATE

Metabolic

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

J Hepatol. 2016 May;64(5):1167-75

Luukkonen PK, Zhou Y, Sädevirta S, Leivonen M, Arola J, Orešič M, Hyötyläinen T, Yki-Järvinen H

2016-05-01

Metabolic

Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD

Sci Rep. 2016 Apr 19;6:24740

Petäjä EM, Zhou Y, Havana M, Hakkarainen A, Lundbom N, Ihalainen J, Yki-Järvinen H

2016-04-19

Platform

Data Safe Havens and Trust: Toward a Common Understanding of Trusted Research Platforms for Governing Secure and Ethical Health Research

JMIR Med Inform. 2016 Jun 21;4(2):e22

Lea NC, Nicholls J, Dobbs C, Sethi N, Cunningham J, Ainsworth J, Heaven M, Peacock T, Peacock A, Jones K, Laurie G, Kalra D

2016-06-21

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Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

Lancet Neurol. 2016 Jul;15(8):857-68

Cuyvers E, Sleegers K

2016-07-15

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A Decade of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Belgium

J Alzheimers Dis. 2016 Aug 10;54(1):383-95.

Somers C, Struyfs H, Goossens J, Niemantsverdriet E, Luyckx J, De Roeck N, De Roeck E, De Vil B, Cras P, Martin JJ, De Deyn PP, Bjerke M, Engelborghs S

2016-08-10

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Validation of microRNAs in Cerebrospinal Fluid as Biomarkers for Different Forms of Dementia in a Multicenter Study

J Alzheimers Dis. 2016 Apr 16;52(4):1321-33.

Müller M, Kuiperij HB, Versleijen AA, Chiasserini D, Farotti L, Baschieri F, Parnetti L, Struyfs H, De Roeck N, Luyckx J, Engelborghs S, Claassen JA, Verbeek MM

2016-05-08

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sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. 

EMBO Mol Med. 2016 May 2;8(5):466-76

Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, Brendel M, Rominger A, Alcolea D, Fortea J, Lleó A, Blesa R, Gispert JD, Sánchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, Traschütz A, Heneka MT, Struyfs H, Engelborghs S, Sleegers K, Van Broeckhoven C, Zetterberg H, Nellgård B, Blennow K, Crispin A, Ewers M, Haass C

2016-05-02

Metabolic

Risk factors for spontaneously self-reported postprandial hypoglycemia after bariatric surgery

J Clin Endocrinol Metab. 2016 Oct;101(10):3600-3607

Nannipieri M, Belligoli A, Guarino D, Busetto L, Moriconi D, Fabris R, Mari A, Baldi S, Anselmino M, Foletto M, Vettor R, Ferrannini E

2016-06-23

Metabolic

Adipose and circulating CCL18 levels associate with metabolic risk factors in women

J Clin Endocrinol Metab. 2016 Jul 26:jc20162390

Eriksson Hogling D, Petrus P, Gao H, Bäckdahl J, Dahlman I, Laurencikiene J, Acosta J, Ehrlund A, Näslund E, Kulyte A, Mejhert N, Andersson DP, Arner P, Rydén M

2016-07-26

Metabolic

The epigenetic signature of systemic insulin resistance in obese women

Diabetologia. 2016 Nov;59(11):2393-405

Arner P, Sahlqvist AS, Sinha I, Xu H, Yao X, Waterworth D, Rajpal D, Loomis AK, Freudenberg JM, Johnson T, Thorell A, Näslund E, Ryden M, Dahlman I

2016-08-18

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Gray matter network disruptions and amyloid beta in cognitively normal adults

Neurobiol Aging. 2016 Jan;37:154-60

Tijms BM, Kate MT, Wink AM, Visser PJ, Ecay M, Clerigue M, Estanga A, Garcia Sebastian M, Izagirre A, Villanua J, Martinez Lage P, van der Flier WM, Scheltens P, Sanz Arigita E, Barkhof F

2016-01-01

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Diagnostic Impact of Cerebrospinal Fluid Biomarker (Pre-)Analytical Variability in Alzheimer's Disease

J Alzheimers Dis. 2016;51(1):97-106

Niemantsverdriet E, Goossens J, Struyfs H, Martin JJ, Goeman J, De Deyn PP, Vanderstichele H, Engelborghs S

2016-02-01

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Impact of APOE-e4 and family history of dementia on gray matter atrophy in cognitively healthy middle-aged adults

Neurobiol Aging 2016 Feb;38:14-20

Ten Kate M, Sanz-Arigita EJ, Tijms BM, Wink AM, Clerique M, Garcia-Sebastian M, Izagirre A, Ecay-Torres M, Estanga A, Villanua J, Vrenken H, Visser PJ, Martinez-Lage P, Barkhof F

2016-02-01

2015

LINK TOPIC TITLE REFERENCE AUTHOR(S) DATE
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Alzheimer's disease - Recent biomarker developments in relation to updated diagnostic criteria

Clin Chim Acta 2015 Sep 20;449:3-8

Höglund K, Fourier A, Perret-Liaudet A, Zetterberg H, Blennow K, Portelius E

2015-09-20

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Validation of the Erlangen Score Algorithm for the prediction of the development of dementia due to AD in pre-dementia subjects

J Alzheimers Dis. 2015 Sep 9;48(2):433-41

Lewczuk P, Kornhuber J, Toledo JB, Trojanowski JQ, Knapik-Czajka M, Peters O, Wiltfang J, Shaw LM

2015-09-09

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Age-stratified prevalence of mild cognitive impairment and dementia in European populations, a systematic review

J Alzheimers Dis. 2015 Sep 9;48(2):355-9

Alexander M, Perera G, Ford L, Arrighi HM, Foskett N, Debove C, Novak G, Gordon MF

2015-09-09

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A novel multi-tissue diagnostic of healthy ageing can determine cognitive health status using blood RNA

Genome Biol. 2015; 16(1): 185

Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJC, Lannfelt L, Kraus WE, Atherton PJ, Howard R,  Gustafsson T, Hodges A, Timmons JA

2015-09-07

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Boosting translational research on Alzheimer's disease in Europe: The Innovative Medicine Initiative AD research platform

Alzheimers Dement. 2015 Sep;11(9):1121-2

Vaudano E, Vannieuwenhuyse B, Van Der Geyten S, van der Lei J, Visser PJ, Streffer J, Ritchie C, McHale D, Lovestone S, Hofmann-Apitius M,Truyen L, Goldman M

2015-09-01

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No evidence to suggest that the use of acetylcholinesterase inhibitors confounds the results of two blood-based biomarker studies in Alzheimer’s disease

J Alzheimers Dis. 2015 Aug 3;47(3):741-50

Chiam JT, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M,Vellas B, Hodges A, Lovestone S, Newhouse S, Dobson RJ, Kiddle SJ, Sattlecker M

2015-08-03

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Biomarkers for Alzheimer's disease: a controversial topic

Lancet Neurol. 2015 Aug;14(8):781-3

Frisoni GB, Visser PJ

2015-08-01

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Generalizability of the disease state index prediction model for identifying patients progressing from mild cognitive impairment to Alzheimer's disease.

J Alzheimers Dis. 2015;44(1):79-92

Hall A, Muñoz-Ruiz M, Mattila J, Koikkalainen J, Tsolaki M, Mecocci P, Kloszewska I, Vellas B, Lovestone S, Visser PJ, Lötjonen J, Soininen H;Alzheimer Disease Neuroimaging Initiative; AddNeuroMed consortium; DESCRIPA and Kuopio L-MCI.

2015-07-07

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Blood protein markers of Neocortical Amyloid Burden: A candidate study using SOMAscan technology

J Alzheimers Dis. 2015 Jun 26;46(4):947

Voyle N, Baker D, Burnham SC, Covin A, Zhang Z, Sangurdekar DP, Tan Hehir CA, Bazenet C, Lovestone S, Kiddle S, Dobson RJ

2015-07-01

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Cerebrospinal fluid P-tau181P: biomarker for improved differential diagnosis

Front Neurol. 2015 Jun 17;6:138

Struyfs H, Niemantsverdriet E, Goossens J, Fransen E, Martin JJ, De Deyn PP, Engelborghs S

2015-06-17

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Plasma protein biomarkers of Alzheimer’s disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes

Transl Psychiatry. 2015 Jun 16;5:e584

Kiddle SJ, Steves CJ, Mehta M, Simmons A, Xu X, Newhouse S, Sattlecker M, Ashton NJ, Bazenet C, Killick R, Adnan J, Westman E, Nelson S,Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Curtis C, Breen G, Williams SC, Lovestone S, Spector TD, Dobson RJ

2015-06-16

Link

Metabolic

Associations between potentially modifiable risk factors and Alzheimer’s disease: A Mendelian randomization study

PLoS Med. 2015 Jun 16;12(6):e1001841

Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JR, Boehme KL, Walter S, Kauwe JS, Gibbons LE; Alzheimer’s Disease Genetics Consortium; GERAD1 Consortium; EPIC-InterAct Consortium, Larson EB, Powell JF, Langenberg C, Crane PK, Wareham NJ, Scott RA

2015-06-09

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Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

JAMA. 2015 May 19; 313(19): 1924–1938

Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FRJ, Visser PJ, and the Amyloid Biomarker Study Group

2015-05-19

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Temporal evolution of biomarkers and cognitive markers in the asymptomatic, MCI, and dementia stage of Alzheimer's disease

Alzheimers Dement. 2015 May;11(5):511-22

Bertens D, Knol DL, Scheltens P, Visser PJ; Alzheimer's Disease Neuroimaging Initiative

2015-05-01

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Importance and impact of pre-analytical variables on Alzheimer’s disease biomarker levels in cerebrospinal fluid

Clin Chem Apr 2015; 61(5):734-743

Le Bastard N, De Deyn PP, Engelborghs S

2015-04-13

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Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage

Brain. 2015 May;138(Pt 5):1327-38

Vos SJ, Verhey F, Frölich L, Kornhuber J, Wiltfang J, Maier W, Peters O, Rüther E, Nobili F, Morbelli S, Frisoni GB, Drzezga A, Didic M, van Berckel BN, Simmons A, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Muscio C, Herukka SK, Salmon E,Bastin C, Wallin A, Nordlund A, de Mendonça A, Silva D, Santana I, Lemos R, Engelborghs S, Van der Mussele S; Alzheimer’s Disease Neuroimaging Initiative, Freund-Levi Y, Wallin ÅK, Hampel H, van der Flier W, Scheltens P, Visser PJ

2015-02-18

Link

Metabolic

Adipose Tissue Morphology Predicts Improved Insulin Sensitivity Following Moderate Weight Loss

Int J Obes (Lond). 2015 Jun;39(6):893-8

Eriksson-Hogling D, Andersson DP, Bäckdahl J, Hoffstedt J, Rössner S, Thorell A, Arner E, Arner P, Rydén M

2015-02-10

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Linking genetics of brain changes to Alzheimer’s disease: sparse whole genome association scan of regional MRI volumes in the ADNI and AddNeuroMed cohorts

J Alzheimers Dis. 2015;45(3):851-64

Khondoker M, Newhouse S, Westman E, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Dobson R,Simmons A; AddNeuroMed consortium; Alzheimer's Disease Neuroimaging Initiative

2015-02-03

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An Integrated Workflow for Multiplex CSF Proteomics and Peptidomics-Identification of Candidate Cerebrospinal Fluid Biomarkers of Alzheimer's Disease

J Proteome Res. 2015 Feb 6;14(2):654-63

Hölttä M, Minthon L, Hansson O, Holmén-Larsson J, Pike I, Ward M, Kuhn K, Rüetschi U, Zetterberg H, Blennow K, Gobom J

2015-02-01

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TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies

Acta Neuropathol Commun. 2015 Apr 1;3:15

Goossens J, Vanmechelen E, Trojanowski JQ, Lee VM, Van Broeckhoven C, van der Zee J, Engelborghs S

2015-02-01

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Overdiagnosing vascular dementia using structural brain imaging for dementia work-up

J Alzheimers Dis. 2015;45(4):1039-43

Niemantsverdriet E, Feyen BF, Le Bastard N, Martin JJ, Goeman J, De Deyn PP, Engelborghs S

2015-01-15

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Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer’s disease

Transl Psychiatry. 2015 Jan 13;5:e494

Proitsi P, Kim M, Whiley L, Pritchard M, Leung R, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Sham P, Lovestone S, Powell JF,Dobson RJ, Legido-Quigley C

2015-01-13

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Diagnostic accuracy of CSF amyloid-β isoforms for early and differential dementia diagnosis

J Alzheimers Dis. 2015;45(3):813-22

Struyfs H, Van Broeck B, Timmers M, Fransen E, Sleegers K, Van Broeckhoven C, De Deyn PP, Streffer JR, Mercken M, Engelborghs S

2015-01-01

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Platform

Reuse of EHRs to Support Clinical Research in a Hospital of Reference

Stud Health Technol Inform. 2015;210:224-6

Mayer MA, Furlong LI, Torre P, Planas I, Cots F, Izquierdo E, Portabella J, Rovira J, Gutierrez-Sacristan A, Sanz F

2015-01-01

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Blood protein predictors of brain amyloid for enrichment in clinical trials?

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring 1 (2015) 48–60

Ashton NJ, Kiddle SJ, Graf J, Ward M, Baird AL, Hye A, Westwood S, Wonga KV, Dobson RJ, Rabinovici GD, Miller BL, Rosen HJ, Torres A, Zhang Z, Thurfjell L, Covini A, Tan Hehir C, Baker D, Bazenet C, Lovestone S, on behalf of the AIBL Research Group

2015-03-01

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Metabolic

Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2

J Hepatol 2015 Mar; 62(3):657-63

Zhou Y, Llauradó G, Oresic M, Hyötyläinen T, Orho-Melander M, Yki-Järvinen H

2015-03-01

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Longitudinal protein changes in blood plasma associated with the rate of cognitive decline in Alzheimer's disease

J Alzheimers Dis. 2015;49(4):1105-14

Sattlecker M, Khondoker M, Proitsi P, Williams S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Dobson RJ

2015-11-23

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Metabolic

Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance

Sci Rep 2015 Dec 17;5:18366

Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A

2015-12-17

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Metabolic

Body mass index and risk of non-alcoholic fatty liver disease: Two electronic health record prospective studies

J Clin Endocrinol Metab 2016 Mar;101(3):945-52

Loomis AK, Kabadi S, Preiss D, Hyde C, Bonato V, St Louis M, Desai J, Gill JM, Welsh P, Waterworth D, Sattar N

2015-12-16

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Metabolic

Definitions of Metabolic Health and Risk of Future Type 2 Diabetes in BMI categories: A Systematic Review and Network Meta-Analysis

Diabetes Care 2015 Nov;38(11):2177-87

Lotta LA, Abbasi A, Sharp SJ, Sahlqvsit AS, Waterworth D, Brosnan JM, Scott RA, Langenberg C, Wareham NJ

2015-11-01

Link

Metabolic

Evidence of a causal association between hyperinsulinaemia and endometrial cancer: A Mendelian randomization analysis

J Natl Cancer Inst 2015 Jul 1;107(9): pii: djv178

Nead KT, Sharp SJ, Thompson DJ, Painter JN, Savage DB, Semple RK, Barker A, Australian National Endometrial Cancer Study Group (ANECS), Perry JR, Attia J, Dunning AM, Easton DF, Holliday E, Lott LA, O'Mara T, McEvoy M, Pharoah PD, Scott RJ, Spurdle AB, Langenberg C, Wareham NJ, Scott RA

2015-07-01

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Alzheimer's disease: a report from the 7th Kuopio Azheimer symposium

Neurodegener Dis Manag 2015 Oct;5(5):379-82

Haapasalo A, Pikkarainen M, Soininen H

 

2015-10-29

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A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis

J Alzheimers Dis 2015 Oct 15;49(3):659-69

Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Hodges A, Kiddle S, Dobson RJ

2015-10-15

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Metabolic

Type 2 diabetes in migrant South Asians: mechanisms, mitigation and management

Lancet Diabetes Endocrinol 2015 Dec;3(12):1004-16

Sattar N, Gill JM

2015-12-01

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Metabolic

Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue

Sci Rep 2015 Oct 5;5:14841

Mardinoglu A, Heiker JT, Gärtner D, Björnson E, Schön MR, Flehmig G, Klöting N, Krohn K, Fasshauer M, Stumvoll M, Nielsen J, Blüher M

2015-10-05

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Challenges and opportunities for exploring patient-level data

Biomed Res Int 2015;2015:150435

Lopes P, Bastião Silva L, Oliveira JL

 

2015-10-04

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Metabolic

The UK10K project identifies rare variants in health and disease

Nature 2015 Oct 1;526(7571):82-90

UK10K Consortium, Walter K, Min JL, Huang J, Crooks L, Memari Y, McCarthy S, Perry JR, Xu C, Futema M, Lawson D, Iotchkova V, Schiffels S, Hendricks AE, Danecek P, Li R, Floyd J, Wain LV, Barroso I, Humphries SE, Hurles ME, Zeggini E, Barrett JC, Plagnol V, Richards JB, Greenwood CM, Timpson NJ, Durbin R, Soranzo N

 

2015-10-01

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The genetic landscape of Alzheimer's disease: clinical implications and perspectives

Genet Med 2015 Aug 27

Van Cauwenberghe C, Van Broeckhoven C, Sleegers K

 

2015-08-27

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Metabolic

The epigenetic signature of subcutaneous fat is linked to altered expression of genes implicated in lipid metabolism in obese women

Clin Epigenetics 2015 Sep 8;7(1):93

Arner P, Sinha I, Thorell A, Rydén M, Dahlman-Wright K, Dahlman I

2015-09-08

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Metabolic

Tyrosine is associated with insulin resistance in longitudinal metabolomic profiling of obese children

J Diabetes Res 2016;2016

Hellmuth C, Kirchberg FF, Lass N, Harder U, Peissner W, Koletzko B, Reinehr T

2015-09-06

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Current developments in dementia risk prediction modelling: An updated systematic review

PLoS One 2015 Sep 3;10(9):2136181

Tang EY, Harrison SL, Errington L, Gordon MF, Visser PJ, Novak G, Dufouil C, Brayne C, Robinson L, Launer LJ, Stephan BC

2015-09-03

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Café Variome: General-Purpose Software for Making Genotype-Phenotype Data Discoverable in Restricted or Open Access Contexts

Hum Mutat 2015 Oct;36(10):957-64

Lancaster O, Beck T, Atlan D, Swertz M, Thangavelu D, Veal C, Dalgleish R, Brookes AJ

 

2015-08-25

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Architecture to summarize patient-level data across borders and countries

Stud Health Technol Inform 2015;216:687-90

Bastião Silva LA, Días C, van der Lei J, Oliveira JL

2015-08-19

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Blood metabolite markers of neocortical amyloid-β burden: Discovery and enrichment using candidate proteins

Transl Psychiatry 2016 Jan 26;6:e719

Voyle N, Kim M, Proitsi P, Ashton NJ, Baird AL, Bazenet C, Hye A, Westwood S, Chung R, Ward M, Rabinovici GD, Lovestone S, Breen G, Legido-Quigley C, Dobson RJ, Kiddle SJ

 

2015-08-18

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C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease

Alzheimers Dement 2015 Dec;11(12):1461-9

De Vos A, Jacobs D, Struyfs H, Fransen E, Andersson K, Portelius E, Andreasson U, De Surgeloose D, Hernalsteen D, Sleegers K, Robberecht C, Van Broeckhoven C, Zetterberg H, Blennow K, Engelborghs S, Vanmechelen E

 

2015-12-01

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Prevalence of Amyloid PET Positivity in Dementia Syndromes: A Meta-Analysis

JAMA 2015 May 19;313(19):1939-49

Ossenkoppele R, Jansen WJ, Rabinovici GD, Knol DL, van der Flier WM, van Berckel BN, Scheltens P, Visser PJ, Amyloid PET Study Group, Verfaillie SC, Zwan MD, Adriaanse SM, Lammertsma AA, Barkhof F, Jaqust WJ, Miller BL, Rosen HJ, Landau SM, Villemagne VL, Rowe CC, Lee DY, Na DL, Seo SW, Sarazin M Roe CM, Sabri O, Barthel H, Koglin N, Hodges J, Leyton CE, Vandenberghe R, van Laere K, Drzezga A, Forster S, Grimmer T, Sánchez-Juan P, Carril JM, Mok V, Camus V, Klunk WE, Cohen AD, Meyer PT, Hellwig S, Newberg A, Frederiksen KS, Fleisher AS, Mintun MA, Wolk DA, Nordberg A, Rinne JO, Chételat G, Lleo A, Blesa R, Fortea J, Madasen K, Rodrigue KM, Brooks DJ

 

2015-05-19

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Metabolic

The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes

Int J Obes (Lond) 2015 Jun;39(6):910-9

Dahlman I, Sinha I, Gao H, Brodin D, Thorell A, Rydén M, Andersson DO, Henriksson J, Perfilyev A, Ling C, Dahlman-Wright K, Arner P

2015-03-18

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Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects

Brain 2015 Sep;138(Pt9):2701-15

Toledo JB, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, Moghekar A, Albert M, Hu WT, Monge Argilés JA, Gorostidi A, Teunissen CE, De Deyn PP, Hyman BT, Molinuevo JL, Frisoni GB, Linazasoro G, de Leon MJ, van der Flier WM, Scheltens O, Blennow K, Shaw LM, Trojanowski JQ, Alzheimer's Disease Neuroimaging Initiative

2015-07-28

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Diffusion kurtosis imaging: a biomarker for early diagnosis of Alzheimer’s disease?

J Alzheimers Dis. 2015; 48(4):937-48

Struyfs H, Van Hecke W, Veraart J, Sijbers J, Slaets S, De Belder M, Wuyts L, Peters B, Sleegers K, Robberecht C, Van Broeckhoven C, De Belder F, Parizel PM, Engelborghs S

2015-10-27

2014

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A 22-SNP Alzheimer risk score correlates with family history, onset age and CSF Aβ42

Alzheimers Dement. 2015 Jun 15. pii: S1552-5260(15)00191-0

Sleegers, Bettens, De Roeck, Van Cauwenberghe, Cuyvers, Verheijen J, Struyfs H, Van Dongen J, Vermeulen S, Engelborghs S,Vandenbulcke M, Vandenberghe R, De Deyn PP, Van Broeckhoven C; BELNEU consortium

2014-12-26

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Diagnostic value of MIBG cardiac scintigraphy for differential dementia diagnosis

Int J Geriatr Psychiatry. 2015 Aug;30(8):864-9

Slaets S, Van Acker F, Versijpt J, Hauth L, Goeman J, Martin JJ, De Deyn PP, Engelborghs S

2014-11-03

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Metabolic

Family history of type 2 diabetes increases the risk of both obesity and its complications: is type 2 diabetes a disease of inappropriate lipid storage?

J Intern Med. 2015 May;277(5):540-51

Cederberg H, Stancáková A, Kuusisto J, Laakso M, Smith U

2014-01-09

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Metabolic

Type 2 diabetes as a disease of ectopic fat?

BMC Med. 2014 Aug 26;12:123

Sattar N, Gill JM

2014-08-26

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Temporal evolution of biomarkers and cognitive markers in the asymptomatic, MCI, and dementia stage of Alzheimer's disease

Alzheimers Dement. 2015 May;11(5):511-22

Bertens D, Knol DL, Scheltens P, Visser PJ; Alzheimer's Disease Neuroimaging Initiative

2014-08-20

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Circulating Proteomic Signatures of Chronological Age

J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):809-16

Menni C, Kiddle SJ, Mangino M, Viñuela A, Psatha M, Steves C, Sattlecker M, Buil A, Newhouse S, Nelson S, Williams S, Voyle N, Soininen H,Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Spector TD, Dobson R, Valdes AM

2014-08-14

Link

Metabolic

Hypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance

J Clin Invest. 2014 Sep;124(9):4028-38

Payne F, Colnaghi R, Rocha N, Seth A, Harris J, Carpenter G, Bottomley WE, Wheeler E, Wong S, Saudek V, Savage D, O'Rahilly S, Carel JC, Barroso I,O'Driscoll M, Semple R

2014-08-08

Link

AD

Depression in mild cognitive impairment is associated with progression to Alzheimer's disease: a longitudinal study

J Alzheimers Dis. 2014;42(4):1239-50

Van der Mussele S, Fransen E, Struyfs H, Luyckx J, Mariën P, Saerens J, Somers N, Goeman J, De Deyn PP, Engelborghs S

2014-07-07

Link

AD

Plasma proteins predict conversion to dementia from prodromal disease

Alzheimers Dement. 2014 Nov;10(6):799-807

Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K,Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S

2014-07-03

Link

Metabolic

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8901-6

Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P,Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB

2014-06-17

Link

Platform

Egas: a collaborative and interactive document curation platform

Database (Oxford). 2014 Jun 11;2014. pii: bau048

Campos D, Lourenço J, Matos S, Oliveira JL

2014-06-11

Link

AD

Validation of the AD-CSF-index in autopsy-confirmed Alzheimer's disease patients and healthy controls

J Alzheimers Dis. 2014;41(3):903-9

Struyfs H, Molinuevo JL, Martin JJ, De Deyn PP, Engelborghs S

2014-04-04

Link

Metabolic

Changes in the serum metabolite profile in obese children with weight loss

Eur J Nutr. 2015 Mar;54(2):173-81

Reinehr T, Wolters B, Knop C, Lass N, Hellmuth C, Harder U, Peissner W, Wahl S, Grallert H, Adamski J, Illig T, Prehn C, Yu Z, Wang-Sattler R, Koletzko B

2014-04-17

Link

AD, Metabolic

Advanced glycation end products, dementia and diabetes

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4743-4

Lovestone S, Smith U

2014-04-01

Link

Metabolic

A population-based study on the prevalence of NASH using scores validated against liver histology

J Hepatol. 2014 Apr;60(4):839-46

Hyysalo J, Männistö VT, Zhou Y, Arola J, Kärjä V, Leivonen M, Juuti A, Jaser N, Lallukka S, Käkelä P, Venesmaa S, Simonen M, Saltevo J, Moilanen L, Korpi-Hyövalti E, Keinänen-Kiukaanniemi S, Oksa H, Orho-Melander M, Valenti L, Fargion S, Pihlajamäki J, Peltonen M, Yki-Järvinen H

2014-04-01

Link

Metabolic

Circulating Triacylglycerol Signatures in Nonalcoholic Fatty Liver Disease Associated With the I148M Variant in PNPLA3 and With Obesity

Diabetes. 2014 Jan;63(1):312-22

Hyysalo J, Gopalacharyulu, Bian H, Hyötyläinen T, Leivonen M, Jaser N, Juuti A, Honka MJ, Nuutila P, Olkkonen VM, Oresic M, Yki-Järvinen H

2014-01-01

Link

Metabolic

Adipose Tissue CIDEA is Associated, Independently of Weight Variation, to Change in Insulin Resistance during a Longitudinal Weight Control Dietary Program in Obese Individuals

PLoS One 2014 Jul; 9(7):e98707

Monastier E, Déjean S, Le Gall C, Saris WH, Langin D, Viguerie N

2014-07-01

Link Platform Medical imaging archiving: a comparison between several NoSQL solutions BHI. 2014, Jun;65-68. LAB Silva, L Beroud, C Costa, JL Oliveira 2014-06-01
Link Platform Normalizing medical imaging archives for dose quality assurance and productivity auditing MeMeA. 2014, Jun;1-6. LAB Silva, L Ribeiro, C Costa, JL Oliveira, M Santos 2014-06-11
Link Platform Semantic search over DICOM repositories 2014 IEEE International Conference on Healthcare Informatics (ICHI). 204, Sept 15-17, p238-246. LAB Silva, C Costa, JL Oliveira 2014-09-15

2013

LINK TOPIC TITLE REFERENCE AUTHOR(S) DATE
Link

AD

Unresolved questions in Alzheimer's research - will biomarkers help?

Biomark Med. 2014;8(1):61-3

Zetterberg H

2013-12-14

Link

Metabolic

Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids. 

Diabetologia. 2013 Oct;56(10):2266-74

Orešic M, Hyötyläinen T, Kotronen A, Gopalacharyulu P, Nygren H, Arola J, Castillo S, Mattila I, Hakkarainen A, Borra RJ, Honka MJ, Verrijken A, Francque S, Iozzo P, Leivonen M, Jaser N, Juuti A, Sørensen TI, Nuutila P, Van Gaal L, Yki-Järvinen H

2013-07-04

Link

AD

Preclinical Alzheimer’s disease and its outcome: a longitudinal cohort study

Lancet Neurol. 2013 Oct;12(10):957-65

Vos SJ, Xiong C, Visser PJ, Jasielec MS, Hassenstab J, Grant EA, Cairns NJ, Morris JC, Holtzman DM, Fagan AM

2013-01-15

Deliverables

EXECUTIVE SUMMARY TOPIC DELIVERABLE DATE

Download deliverable

Platform

D9.4 - Second framework evaluation results and requirements v3

2016-12-31

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Platform

D10.4 - First draft of the EMIF Ethical Code of Practice

2016-12-31

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Platform

D11.5 - Second version of the harmonised information model and associated terminology mapping

2016-12-31

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Platform

D14.9 - System implementation feedback and evaluation report, iteration 3

2016-12-31

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Platform

D14.10 - EMIF Platform, version 4

2016-12-31

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Platform

D15.6 - Update to Business Plan - February 2017

2016-12-31

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PMO

D16.16 - Technical and Financial Annual Reports #4

2016-12-31

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AD

D3.3 - 2 Proteomic based CSF markers for prognosis

2016-12-31

Download D1.2

AD

D1.2 - Private Remote Research database environment with pooled data from research cohorts

2015-06-30

Download D2.1

AD

D2.1 - Summary statistics of cohorts included

2015-12-31

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AD

D2.2 - Validated criteria for presymptomatic AD and prodromal AD

2015-12-31

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AD

D2.3 - Definition of extreme phenotypes based on cognitive decline

2015-12-31

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AD

D2.4 - Prediction model for cognitive decline

2015-12-31

Download D2.5

AD

D2.5 - Definition of extreme phenotypes based on AD biomarkers

2015-12-31

Download D1.1

AD

D1.1 - Report on the overview of available data sources

2013-12-31

Download D5.1

Metabolic

D5.1 - Establishing functional datawarehousing and management

2013-12-31

Download D6.1

Metabolic

D6.1 - Analytical framework to investigate metabolic predictors of the complications of obesity

2013-12-31

Download D6.2

Metabolic

D6.2 - A report describing the systematic review of candidate biomarkers for the prediction of the metabolic consequences of obesity

2014-06-30

Download D6.8

Metabolic

D6.8 - Investigation of the causal nature of associations between obesity and selected obesity-related complications

2014-12-31

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Metabolic

D6.3 - A report describing the association of up to 6 candidate biomarkers with metabolic traits in up to 20 000 participants in well-phenotyped metabolically phenotyped studies

2015-12-31

Download D6.4

Metabolic

D6.4 - A report describing the association of a metabolomic profile with the metabolic complications of obesity in up to 20 000 participants in well-phenotyped metabolically phenotyped studies

2015-12-31

Download D9.2

Platform

D9.2 - Platform requirements v1 and evaluation plan

2013-12-31

Download D10.3

Platform

D10.3 - Full database fingerprinting

2013-12-31

Download D11.2

Platform

D11.2 - First version of common data model and associated terminology mapping

2013-12-31

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Platform

D12.1 - Data extraction software v1

2013-12-31

Download D14.2

Platform

D14.2 - A data management solution for vertical projects, version 1

2013-12-31

Download D14.3

Platform

D14.3 - EMIF-Platform, version 1

2013-12-31

Download D15.1

Platform

D15.1 - Report on business models for data exploitation in biosciences

2013-12-31

Download D14.4

Platform

D14.4 - System implementation feedback and evaluation report, iteration 1

2014-04-30

Download D11.3

Platform

D11.3 - Extended specification of the semantic framework of reference

2014-06-30

Download D13.1

Platform

D13.1 - Evaluation of technologies and tools available for data analysis and visualization

2014-06-30

Download D9.1

Platform

D9.1 - Initial requirements set

2013-02-28

Download D15.2

Platform

D15.2 - Market analysis: usage models and data sources characterization

2014-08-31

Download D9.3

Platform

D9.3 - Interim framework evaluation results and requirements v2

2014-12-31

Download D12.2

Platform

D12.2 - Data extraction software v2

2014-12-31

Download D12.3

Platform

D12.3 - Interim report on primary data flows, benchmarking and quality analyses

2014-12-31

Download 13.2

Platform

D13.2 - Data analysis tools for vertical projects v1

2014-12-31

Download D14.5

Platform

D14.5 - A data management solution for vertical projects, v2

2014-12-31

Download D14.6

Platform

D14.6 - EMIF-Platform, version 2

2014-12-31

Download D15.3

Platform

D15.3 - Initial business model description

2014-12-31

Download D11.4

Platform

D11.4 - Second version of common data model and associated terminology mapping

2014-12-31

Download 15.4

Platform

D15.4 - First report on outreach activities: leveraging with related initiatives, contacts with external data sources and with key stakeholders

2015-04-30

Download D10.1

Platform

D10.1 - Initial database fingerprinting

2013-03-31

Download 13.3

Platform

D13.3 - Data analysis and visualization tools, including workflows for linkage with omics data v1

2015-06-30

Download D14.7

Platform

D14.7 - First EMIF-Platform architecture stack

2015-08-31

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Platform

D11.4 - First complete version of the harmonised information model and associated terminology mapping

2015-12-31

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Platform

D12.4 - Interim report on data linkage

2015-12-31

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Platform

D12.5 - Interim report on specialised data extraction, benchmarking, aggregation and processing

2015-12-31

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Platform

D13.4 - Data analysis tools for vertical projects v2

2015-12-31

Download D14.8

Platform

D14.8 - EMIF-Platform, version 3

2015-12-31

Download D15.5

Platform

D15.5 - First draft of business plan

2015-12-31

Download D10.2

Platform

D10.2 - First report on federation procedures, ethical and legal issues

2013-06-30

Download D11.1

Platform

D11.1 - Initial specification of the semantic framework of reference

2013-06-30

Download D14.1

Platform

D14.1 - First report on EMIF-Platform desing and architecture including specifications for privacy protection tools and services

2013-06-30

Download D14.1

Platform

D13.5 - Data analysis and visualisation tools, including workflows for linkage with omics data v2

2016-10-31

Download D16.1

PMO

D16.1 - Operational portal to allow internal team information dissemination, team collaboration, and team document storage

2013-01-31

Download D16.12

PMO

D16.12 - Technical and financial annual report #1

2013-12-31

Download D16.11

PMO

D16.11 - Updated project and risk plans for WP1-15

2014-12-31

Download D16.13

PMO

D16.13 - Technical and financial annual report #2

2014-12-31

Download D16.2

PMO

D16.2 - Templates for dissemination materials: logo design, ppt and poster templates, newsletter formats

2013-03-31

Download D16.14

PMO

D16.14 - Interim assessment of the project

2015-08-31

Download D16.15

PMO

D16.15 - Technical and financial annual report #3

2015-12-31

Download D16.4

PMO

D16.4 - Communication plan

2013-06-30

Download D16.5

PMO

D16.5 - Project handbook

2013-06-30

Download D16.6

PMO

D16.6 - Guidance document for EMIF scientific publications

2013-06-30

Download D16.9

PMO

D16.9 - Operational website for both internal use and external dissemination

2013-06-30

Download 16.10

PMO

D16.10 - Detailed project and risk plans for WP1-15

2013-06-30