By connecting relevant cohort studies across Europe, EMIF-AD will drive setting up a pan-European new platform for large-scale research on biomarkers and risk factors for neurodegenerative disorders. The biomarker discovery activities envisaged for EMIF-AD will be driven by an extreme phenotype approach, in which decline or biomarker status is used as the end point for biomarker discovery, rather than a clinical diagnosis. Doing so, EMIF-AD aims at developing new treatment targets, multimodality/omics diagnostic tools and qualification level biomarker datasets suitable for presentation to regulatory authorities prior to approval for use in clinical trials and practice.
Finally, development of prediction rules for cognitive decline in presymptomatic and prodromal AD will not only improve clinical diagnosis and prognosis, but equally support subject selection and stratification in future clinical trials. To reach these objectives the EMIF-AD team will combine both large-scale patient cohorts, linkage with EHR data, and cutting edge biomarker discovery expertise.